Structure elucidation of Sch 725674 from Aspergillus sp

J Antibiot (Tokyo). 2005 Aug;58(8):535-8. doi: 10.1038/ja.2005.74.

Abstract

A new macrolide Sch725674 (1) was isolated and identified from the culture of an Aspergillus sp. The structure elucidation of 1 was accomplished based on extensive NMR spectroscopic analyses. Compound 1 showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 32 microg/ml, respectively.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Aspergillus / chemistry*
  • Candida albicans / drug effects
  • Macrolides / chemistry
  • Macrolides / isolation & purification
  • Macrolides / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Saccharomyces cerevisiae / drug effects

Substances

  • Antifungal Agents
  • Macrolides
  • Sch 725674