Age-related change in neural processing of time-dependent stimulus features

Brain Res Cogn Brain Res. 2005 Dec;25(3):913-25. doi: 10.1016/j.cogbrainres.2005.09.014. Epub 2005 Oct 27.

Abstract

Aging is associated with changes in automatic processing of task-irrelevant stimuli, and this may lead to functional disturbances including repeated orienting to nonnovel events and distraction from task. The effect of age on automatic processing of time-dependent stimulus features was investigated by measurement of the auditory mismatch negativity (MMN) in younger (18-23) and older (55-85) adults. Amplitude of MMN recorded during a paradigm involving low-probability deviation in interstimulus interval (from 500 ms to 250 ms) was found to be reduced in the older group at fronto-central sites. This effect was paralleled by, and correlated to, decreased sensory gating efficiency for component N1 recorded during a separate paradigm involving alternate presentation of auditory stimuli at long (9 s) and short (0.5 s) interstimulus intervals. Further, MMN amplitude was correlated to behavioral performance on a small subset of neuropsychological tests, including the Rey Auditory Verbal Learning Test, within a group of healthy older adults. The results support the hypothesis that aging is associated with declines in automatic processing of time-dependent stimulus features, and this is related to cognitive function. These conclusions are considered in the context of age-related declines in prefrontal cortex function and associated increases in susceptibility to task-irrelevant stimuli.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Aged, 80 and over
  • Aging / physiology*
  • Attention / physiology*
  • Electroencephalography
  • Electrophysiology
  • Female
  • Frontal Lobe / physiology
  • Humans
  • Learning / physiology
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Psychomotor Performance / physiology
  • Reaction Time / physiology
  • Time Factors
  • Verbal Learning / physiology