Development of new dosimetry using extended DNA fibers

Sachihiro Matsunaga; Kazutaka Ohshio; Erimu Harada; Shinsuke Fujiwara; Susumu Uchiyama; Kiichi Fukui

doi:10.1016/S1389-1723(04)00300-7

Development of new dosimetry using extended DNA fibers

J Biosci Bioeng. 2004;98(5):384-6. doi: 10.1016/S1389-1723(04)00300-7.

Authors

Sachihiro Matsunaga¹, Kazutaka Ohshio, Erimu Harada, Shinsuke Fujiwara, Susumu Uchiyama, Kiichi Fukui

Affiliation

¹ Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

PMID: 16233724
DOI: 10.1016/S1389-1723(04)00300-7

Abstract

We applied fluorescent microscopy to monitor the damage of DNA upon exposure to gamma radiation. Our developed dosimetry demonstrated that the number of breaks in DNA is proportional to the dose of the irradiation but is not dependent on dose rate of the irradiation and the GC content of DNA.