Fluorescent microscopic study of epithalon binding in maternal and fetal rabbit tissues in health and under conditions of placental insufficiency

E A Lapina; L A Nazarova; O P Petrova; D A Sibarov; L B Zubzhitskaya; N G Pavlova; N N Konstantinova; Ya S Konovalov; I M Kvetnoi; A V Arutyunyan; E I Grigorev

doi:10.1007/s10517-005-0359-2

Fluorescent microscopic study of epithalon binding in maternal and fetal rabbit tissues in health and under conditions of placental insufficiency

Bull Exp Biol Med. 2005 May;139(5):615-8. doi: 10.1007/s10517-005-0359-2.

[Article in English, Russian]

Authors

E A Lapina¹, L A Nazarova, O P Petrova, D A Sibarov, L B Zubzhitskaya, N G Pavlova, N N Konstantinova, Ya S Konovalov, I M Kvetnoi, A V Arutyunyan, E I Grigorev

Affiliation

¹ St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences. eiisalap@mail.ru

PMID: 16224563
DOI: 10.1007/s10517-005-0359-2

Abstract

Epithalon (regulatory tetrapeptide) labeled with dansil (fluorescent stain) easily penetrates into all tissues and organs of pregnant rabbit females and through the placenta into fetal organs. Incorporation of labeled epithalon in placental tissues is more often observed in fetuses developing under conditions of placental insufficiency than in normal fetuses.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Female
Fetus / anatomy & histology*
Fetus / physiology
Microscopy, Fluorescence
Oligopeptides / metabolism*
Placenta / anatomy & histology
Placental Insufficiency / physiopathology*
Pregnancy
Protein Binding
Rabbits
Uterus / blood supply

Substances

Oligopeptides
alanyl-glutamyl-aspartyl-glycine