Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials

J Am Chem Soc. 2005 Oct 19;127(41):14473-8. doi: 10.1021/ja054169u.

Abstract

In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Animals
  • Cattle
  • Glycoproteins / chemistry*
  • Gold / chemistry
  • Humans
  • Microscopy, Atomic Force / methods
  • Molecular Structure
  • Particle Size
  • Phosphorylcholine / chemical synthesis
  • Phosphorylcholine / chemistry*
  • Serum Albumin, Bovine / chemistry*
  • Spectrometry, X-Ray Emission / methods
  • Static Electricity
  • Sulfhydryl Compounds / chemical synthesis
  • Sulfhydryl Compounds / chemistry
  • Surface Properties
  • Time Factors

Substances

  • Glycoproteins
  • Sulfhydryl Compounds
  • Phosphorylcholine
  • Serum Albumin, Bovine
  • Gold