Abstract
The mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg functions as a scaffolding protein that facilitates the transmission of diverse signals. In the present study, we attempted to identify the downstream target genes of Dlg, and found that Dlg up-regulates expression of the ELR+ CXC chemokine Scyb5, which has been implicated in the immune system. Our finding suggests that Scyb5 may play an important role in the tumor suppressor function of Dlg.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Cells, Cultured
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Chemokine CXCL5
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Chemokines, CXC / biosynthesis*
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Chemokines, CXC / genetics
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Discs Large Homolog 1 Protein
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Gene Expression Profiling
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Guanylate Kinases
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Humans
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Membrane Proteins
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Mice
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Proteins / metabolism*
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Tumor Suppressor Proteins / metabolism*
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Up-Regulation
Substances
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Adaptor Proteins, Signal Transducing
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Chemokine CXCL5
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Chemokines, CXC
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Cxcl5 protein, mouse
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DLG1 protein, human
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Discs Large Homolog 1 Protein
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Dlg1 protein, mouse
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Membrane Proteins
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Proteins
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Tumor Suppressor Proteins
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Guanylate Kinases