The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR+ CXC chemokine Scyb5

Biochem Biophys Res Commun. 2005 Nov 11;337(1):191-4. doi: 10.1016/j.bbrc.2005.09.037.

Abstract

The mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg functions as a scaffolding protein that facilitates the transmission of diverse signals. In the present study, we attempted to identify the downstream target genes of Dlg, and found that Dlg up-regulates expression of the ELR+ CXC chemokine Scyb5, which has been implicated in the immune system. Our finding suggests that Scyb5 may play an important role in the tumor suppressor function of Dlg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Cells, Cultured
  • Chemokine CXCL5
  • Chemokines, CXC / biosynthesis*
  • Chemokines, CXC / genetics
  • Discs Large Homolog 1 Protein
  • Gene Expression Profiling
  • Guanylate Kinases
  • Humans
  • Membrane Proteins
  • Mice
  • Proteins / metabolism*
  • Tumor Suppressor Proteins / metabolism*
  • Up-Regulation

Substances

  • Adaptor Proteins, Signal Transducing
  • Chemokine CXCL5
  • Chemokines, CXC
  • Cxcl5 protein, mouse
  • DLG1 protein, human
  • Discs Large Homolog 1 Protein
  • Dlg1 protein, mouse
  • Membrane Proteins
  • Proteins
  • Tumor Suppressor Proteins
  • Guanylate Kinases