Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors

Manik Pullagurla; Uma Siripurapu; Renata Kolanos; Mikhail L Bondarev; Małgorzata Dukat; V Setola; B L Roth; Richard A Glennon

doi:10.1016/j.bmcl.2005.08.059

Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. doi: 10.1016/j.bmcl.2005.08.059. Epub 2005 Sep 23.

Authors

Manik Pullagurla¹, Uma Siripurapu, Renata Kolanos, Mikhail L Bondarev, Małgorzata Dukat, V Setola, B L Roth, Richard A Glennon

Affiliation

¹ Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.

PMID: 16183286
DOI: 10.1016/j.bmcl.2005.08.059

Abstract

An examination of several amine-substituted analogs of N(1)-benzenesulfonylindoles reveals that although they bind at human 5-HT(6) serotonin receptors with high affinity, they are likely to bind in a dissimilar manner.

Publication types

Comparative Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Amines / chemistry
Humans
Indoles / chemistry*
Protein Binding
Receptors, Serotonin / chemistry*

Substances

Amines
Indoles
Receptors, Serotonin
serotonin 6 receptor

Grants and funding

MH60599/MH/NIMH NIH HHS/United States