Relation of left ventricular diastolic function as measured by echocardiography and pulmonary capillary wedge pressure to rejection in young patients (< or = 31 years) after heart transplantation

Lucy Y Eun; Robert J Gajarski; Joseph N Graziano; Gregory J Ensing

doi:10.1016/j.amjcard.2005.04.060

Relation of left ventricular diastolic function as measured by echocardiography and pulmonary capillary wedge pressure to rejection in young patients (< or = 31 years) after heart transplantation

Am J Cardiol. 2005 Sep 15;96(6):857-60. doi: 10.1016/j.amjcard.2005.04.060.

Authors

Lucy Y Eun¹, Robert J Gajarski, Joseph N Graziano, Gregory J Ensing

Affiliation

¹ Department of Pediatrics, Division of Pediatric Cardiology, University of Michigan, Ann Arbor, Michigan, USA.

PMID: 16169377
DOI: 10.1016/j.amjcard.2005.04.060

Abstract

To investigate the association of catheter-derived and newer echocardiographically derived measures of diastolic function with rejection in heart transplant recipients, 48 transplant recipients had Doppler and Doppler tissue imaging assessment along with catheter-measured pulmonary capillary wedge pressure (PCWP) at the time of endomyocardial biopsy. Of echocardiographic measures, propagation velocity (Vp), mitral E-wave velocity (E)/Vp, and E/annular mitral E-wave velocity (Em) were significantly associated with rejection (p <0.02), and an elevated PCWP was associated with rejection (p = 0.023) but with poor sensitivity. Weak but insignificant correlations with PCWP were found for E/Vp (r = 0.28) and E/Em (r = 0.37).

MeSH terms

Adolescent
Adult
Child
Child, Preschool
Cohort Studies
Echocardiography, Doppler, Color*
Female
Graft Rejection / diagnostic imaging*
Graft Rejection / physiopathology*
Heart Transplantation / diagnostic imaging*
Humans
Male
Predictive Value of Tests
Prospective Studies
Pulmonary Wedge Pressure*
Sensitivity and Specificity
Ventricular Function, Left*