Purpose: To investigate the effects of recombinant human growth hormone(rh-GH )on mandibular bone loss with or without teeth in the ovariectomized rats.
Methods: Three-month aged ovariectomized rats were utilized as postmenopausal osteoporosis models and all the molars in left mandibles were extracted. After operations, the rats began to receive rh-GH 1 mg.kg(-1).d(-1) with subcutaneous injection for ten days. Weight of the rats ,mineral density of the mandibular bone and 3 other parameters were measured at 8th week and 12th week. The data was analyzed with F and t test.
Results: The weight of the rats increased and mandibular bone mineral density of the rats were significantly improved after rh-GH treatment, P<0.05.
Conclusion: Rh-GH can increase the weight of the old rats and restore mandibular bone mass in mandibles with or without teeth.