Abstract
In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.
MeSH terms
-
Child
-
Cohort Studies
-
Drug Resistance, Neoplasm / genetics
-
Gene Expression Regulation / drug effects
-
Gene Expression Regulation / physiology
-
Glucocorticoids / biosynthesis
-
Humans
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
-
Prednisolone / therapeutic use*
-
Protein Isoforms / biosynthesis
-
Receptors, Glucocorticoid / biosynthesis*
-
Receptors, Glucocorticoid / genetics
Substances
-
Glucocorticoids
-
Protein Isoforms
-
Receptors, Glucocorticoid
-
Prednisolone