Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats

Epilepsy Res. 2005 Aug-Sep;66(1-3):199-202. doi: 10.1016/j.eplepsyres.2005.07.006.

Abstract

Inhibitory postsynaptic currents were measured in CA1 pyramidal cells from chronically epileptic rats (pilocarpine model). Tiagabine, a selective inhibitor of the GABA-uptake transporter 1 prolonged currents equally to cells from control animals. Thus, GABA-uptake has an unaltered impact on inhibitory synaptic efficacy in rats with chronic temporal lobe epilepsy, underlining the rational for the use of GABA-uptake blockers in this condition.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Chronic Disease
  • Disease Models, Animal
  • Epilepsy / chemically induced
  • Epilepsy / metabolism*
  • GABA Agonists / pharmacology
  • Hippocampus / cytology*
  • In Vitro Techniques
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Membrane Potentials / radiation effects
  • Muscarinic Agonists / pharmacology
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Neurons / drug effects
  • Neurons / physiology*
  • Nipecotic Acids / pharmacology
  • Patch-Clamp Techniques / methods
  • Pilocarpine / pharmacology
  • Rats
  • Synapses / drug effects
  • Synapses / metabolism*
  • Tiagabine
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • GABA Agonists
  • Muscarinic Agonists
  • Nipecotic Acids
  • Pilocarpine
  • gamma-Aminobutyric Acid
  • Tiagabine