[Improved osseointegration of titanium implants after surface coating with polymers in a rabbit model]

F Thorey; F Witte; J Nellesen; N Griep-Raming; H Menzel; G Gross; A Hoffmann; J Seufert; H Windhagen

doi:10.1007/s00132-005-0852-3

[Improved osseointegration of titanium implants after surface coating with polymers in a rabbit model]

Orthopade. 2005 Nov;34(11):1112, 1114-7. doi: 10.1007/s00132-005-0852-3.

[Article in German]

Authors

F Thorey¹, F Witte, J Nellesen, N Griep-Raming, H Menzel, G Gross, A Hoffmann, J Seufert, H Windhagen

Affiliation

¹ Orthopädische Klinik II im Annastift, Medizinische Hochschule, Hannover. thorey@annastift.de

PMID: 16133156
DOI: 10.1007/s00132-005-0852-3

Abstract

In this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.

Publication types

Evaluation Study

MeSH terms

Animals
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins / administration & dosage*
Bone Morphogenetic Proteins / chemistry
Coated Materials, Biocompatible / chemistry*
Drug Delivery Systems
Feasibility Studies
Femur / drug effects
Femur / pathology
Femur / physiopathology*
Femur / surgery*
Materials Testing
Osseointegration / drug effects*
Pilot Projects
Rabbits
Surface Properties
Titanium / chemistry*
Transforming Growth Factor beta / administration & dosage*
Transforming Growth Factor beta / chemistry
Treatment Outcome

Substances

Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Coated Materials, Biocompatible
Transforming Growth Factor beta
Titanium