Abstract
A wide variety of 3-halospiro[4.5]trienones are readily prepared in good to excellent yields by the intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes under mild reaction conditions. ICl, I2, and Br2 are all effective electrophiles for this process under carefully optimized reaction conditions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkynes / chemistry*
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Anisoles / chemistry*
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Cyclization
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Hydrocarbons, Halogenated / chemistry
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Models, Chemical
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Molecular Structure
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Spiro Compounds / chemical synthesis*
Substances
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Alkynes
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Anisoles
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Hydrocarbons, Halogenated
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Spiro Compounds
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anisole