Arabinose-derived ketones as catalysts for asymmetric epoxidation of alkenes

J Org Chem. 2005 Sep 2;70(18):7279-89. doi: 10.1021/jo050928f.

Abstract

[reaction: see text] Readily available arabinose-derived ketones, containing a tunable butane-2,3-diacetal as the steric blocker, displayed increasing enantioselectivity (up to 90% ee) with the size of the acetal alkyl group in catalytic asymmetric epoxidation of trans-disubstituted and trisubstituted alkenes. The stereochemical communication between our ketone catalysts and the alkene substrates is mainly due to steric effect, and electronic effect involving pi-pi interaction between phenyl groups of substrate and of catalyst did not appear to be operative in our system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Arabinose / chemistry*
  • Catalysis
  • Epoxy Compounds / chemical synthesis*
  • Ketones / chemistry*

Substances

  • Alkenes
  • Epoxy Compounds
  • Ketones
  • Arabinose