An alternative agglutination assay to measure antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes

Trans R Soc Trop Med Hyg. 2003 Nov-Dec;97(6):717-9. doi: 10.1016/s0035-9203(03)80111-6.

Abstract

Agglutination assays detect antibodies to variant parasite antigens expressed on the surface of Plasmodium falciparum-infected erythrocytes. Standard techniques require immediate analysis limiting the number of samples that can be processed simultaneously and preclude re-examination of slides. Fixed Giemsa-stained smears allow long-term storage and re-examination, without fluorescence microscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agglutination Tests / methods*
  • Animals
  • Antibodies, Protozoan / blood*
  • Antigens, Surface / immunology*
  • Erythrocytes / immunology*
  • Erythrocytes / parasitology
  • Female
  • Humans
  • Malaria, Falciparum / diagnosis*
  • Male
  • Plasmodium falciparum / immunology*
  • Pregnancy / immunology

Substances

  • Antibodies, Protozoan
  • Antigens, Surface