Abstract
Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Botulinum Toxins, Type A / administration & dosage*
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Botulinum Toxins, Type A / adverse effects
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Cross-Over Studies
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Disability Evaluation
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Double-Blind Method
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Female
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Gait Disorders, Neurologic / drug therapy*
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Gait Disorders, Neurologic / etiology
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Gait Disorders, Neurologic / physiopathology
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Humans
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Male
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Middle Aged
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Muscle, Skeletal / drug effects*
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Muscle, Skeletal / physiopathology
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Parkinson Disease / complications
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Parkinson Disease / drug therapy*
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Parkinson Disease / physiopathology
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Placebos
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Surveys and Questionnaires
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Treatment Failure
Substances
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Placebos
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Botulinum Toxins, Type A