Acid normalization and improved esophageal motility after Nissen fundoplication: equivalent outcomes in patients with normal and ineffective esophageal motility

Am J Surg. 2005 Sep;190(3):445-50. doi: 10.1016/j.amjsurg.2005.05.040.

Abstract

Background: Severe gastroesophageal reflux disease may result in acquired esophageal dysmotility. The correct surgical approach to associated gastroesophageal reflux disease and dysmotility is controversial, in particular whether the "gold-standard" total fundoplication of Nissen is appropriate compared with partial fundoplication. Our unit has performed total fundoplication for all patients, irrespective of esophageal motility, and this article describes that experience.

Methods: Ninety-eight patients undergoing antireflux surgery were divided into 2 groups. Group 1 (n=60) consisted of patients with normal esophageal motility, and group 2 (n=38) had dysmotility. All patients underwent preoperative and postoperative manometry, 24-hour pH testing, symptom scoring, and quality-of-life assessment.

Results: The median postoperative acid score was not significantly different between groups 1 and 2. Eighty-eight percent of patients with normal motility and 89% of patients with dysmotility had no symptoms or minor symptoms, with a significant improvement in quality of life 6 months after surgery. There was a significant increase in esophageal wave amplitude in both groups, and 20 patients (53%) in the dysmotility group reverted to normal motility after surgery. Recurrent symptoms were associated with postoperative abnormal pH profiles in 5 patients from group 1 and 3 from group 2.

Conclusions: Preoperative dysmotility is not a contraindication for total fundoplication. Postoperative acid control is associated with improved esophageal clearance and symptoms.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Esophageal Motility Disorders / diagnosis
  • Esophageal Motility Disorders / physiopathology
  • Esophageal Motility Disorders / surgery*
  • Female
  • Fundoplication / methods*
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / physiopathology*
  • Gastroesophageal Reflux / surgery*
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Manometry
  • Middle Aged
  • Postoperative Complications
  • Prospective Studies
  • Quality of Life
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Treatment Outcome