Abstract
Integrin signaling is bidirectional. 'Inside-out' signals regulate integrin affinity for adhesive ligands, and ligand-dependent 'outside-in' signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified. However, a key unresolved question is how integrins propagate signals across the plasma membrane.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Cell Membrane / metabolism
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Cell Membrane / physiology
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Humans
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Integrins / metabolism*
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Integrins / physiology
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Models, Molecular
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Molecular Sequence Data
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Phosphates / metabolism
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Protein Conformation
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Protein Kinases / metabolism
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Protein Structure, Tertiary
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Signal Transduction / physiology*
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Talin / metabolism
Substances
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Integrins
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Phosphates
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Talin
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Protein Kinases