Stannous chloride in alcohol: a one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones

J Org Chem. 2005 Aug 19;70(17):6941-3. doi: 10.1021/jo050450f.

Abstract

A novel one-step synthesis of 2,3-dihydro-1H-quinazolin-4-ones from 2-nitrobenzamides is reported. These reactions are mediated by stannous chloride in 0.02 M methanolic or ethanolic HCl solution and proceed in good yields.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alcohols / chemistry*
  • Benzamides / chemistry*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Quinazolines / chemical synthesis*
  • Tin Compounds / chemistry*

Substances

  • Alcohols
  • Benzamides
  • Quinazolines
  • Tin Compounds
  • stannous chloride