Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation

J Virol. 2005 Aug;79(15):10088-92. doi: 10.1128/JVI.79.15.10088-10092.2005.

Abstract

We previously reported that Tax-specific CD8(+) cytotoxic T lymphocytes (CTLs), directed to single epitopes restricted by HLA-A2 or A24, expanded in vitro and in vivo in peripheral blood mononuclear cells (PBMC) from some adult T-cell leukemia (ATL) patients after but not before allogeneic hematopoietic stem cell transplantation (HSCT). Here, we demonstrated similar Tax-specific CTL expansion in PBMC from another post-HSCT ATL patient without HLA-A2 or A24, whose CTLs equally recognized two newly identified epitopes, Tax88-96 and Tax272-280, restricted by HLA-A11, suggesting that these immunodominant Tax epitopes are present in the ATL patient in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Coculture Techniques
  • Epitopes / immunology*
  • Gene Products, tax / genetics
  • Gene Products, tax / immunology*
  • HLA-A Antigens / immunology*
  • Human T-lymphotropic virus 1 / immunology
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / immunology*
  • Leukemia-Lymphoma, Adult T-Cell / therapy*
  • Leukocytes, Mononuclear
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Peptides / genetics
  • Stem Cell Transplantation*
  • T-Cell Antigen Receptor Specificity
  • T-Lymphocytes, Cytotoxic / immunology*
  • Transplantation, Homologous

Substances

  • Epitopes
  • Gene Products, tax
  • HLA-A Antigens
  • Peptides