Abstract
The authors examined the records of 149 children with language regression (LR) who had overnight EEG monitoring. Children with isolated LR had a higher frequency of epileptiform abnormalities (60%) than those with LR in the context of autistic regression (31%, p = 0.002) and also a higher rate of clinical seizures (33% vs 8%, p < 0.001). EEG abnormalities in the LR only group were also more prominent. This suggests two subtypes of language regression.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Action Potentials / physiology
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Age of Onset
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Autistic Disorder / complications*
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Autistic Disorder / diagnosis
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Autistic Disorder / physiopathology*
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Cerebral Cortex / physiopathology
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Child, Preschool
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Disease Progression
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Electroencephalography
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Epilepsy / complications*
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Epilepsy / diagnosis
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Epilepsy / physiopathology*
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Female
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Humans
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Language Development Disorders / diagnosis
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Language Development Disorders / etiology*
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Language Development Disorders / physiopathology*
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Male
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Monitoring, Physiologic
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Polysomnography
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Predictive Value of Tests
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Prognosis
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Regression, Psychology
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Retrospective Studies
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Sex Factors