[A charge-deficient analogue of spermine with chelating properties]

A R Khomutov; N A Grigorenko; A V Demin; J Vepsalainen; R A Casero; P M Woster

doi:10.1007/s11171-005-0037-1

[A charge-deficient analogue of spermine with chelating properties]

Bioorg Khim. 2005 May-Jun;31(3):303-11. doi: 10.1007/s11171-005-0037-1.

[Article in Russian]

Authors

A R Khomutov, N A Grigorenko, A V Demin, J Vepsalainen, R A Casero, P M Woster

PMID: 16004389
DOI: 10.1007/s11171-005-0037-1

Abstract

1,12-Diamino-3,6,9-triazadodecane, a new isosteric and charge-deficient analogue of spermine, is synthesized. Unlike spermine, the new analogue is an excellent chelator of Cu2+ ions. Possible applications of this compound for studying enzymes of polyamine metabolism and cellular functions of spermine are discussed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2005, vol. 31, no. 3; see also http://www.maik.ru.

Publication types

English Abstract

MeSH terms

Chelating Agents / chemical synthesis
Chelating Agents / chemistry*
Copper / chemistry*
Spermine / analogs & derivatives*
Spermine / chemical synthesis
Spermine / chemistry*

Substances

1,12-diamino-3,6,9-triazadodecane
Chelating Agents
Spermine
Copper

Grants and funding

R01 CA085509/CA/NCI NIH HHS/United States