Design, syntheses, and biological evaluations of squamostolide and its related analogs

Cheng-Lin Lee; Chi-Fong Lin; Wan-Ru Lin; Kun-Sheng Wang; Ya-Her Chang; Shinne-Ren Lin; Yang-Chang Wu; Ming-Jung Wu

doi:10.1016/j.bmc.2005.05.050

Design, syntheses, and biological evaluations of squamostolide and its related analogs

Bioorg Med Chem. 2005 Oct 15;13(20):5864-72. doi: 10.1016/j.bmc.2005.05.050.

Authors

Cheng-Lin Lee¹, Chi-Fong Lin, Wan-Ru Lin, Kun-Sheng Wang, Ya-Her Chang, Shinne-Ren Lin, Yang-Chang Wu, Ming-Jung Wu

Affiliation

¹ Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.

PMID: 15993613
DOI: 10.1016/j.bmc.2005.05.050

Abstract

Squamostolide and its related analogs were designed and synthesized for biological evaluation. All these compounds were tested for growth inhibition activities against human tumor cell lines, in which one of the compounds showed the most potent cytotoxicity among these derivatives against a full panel of 60 human cancer cell lines. The same compound also showed G2/M phase arrest and a weak apoptotic effect during flow cytometric analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Alkynes / pharmacology*
Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Division / drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
G2 Phase / drug effects
Humans
Lactones / chemistry*
Lactones / pharmacology*

Substances

Alkynes
Antineoplastic Agents, Phytogenic
Lactones
squamostolide