A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo

Biomaterials. 2005 Nov;26(33):6477-86. doi: 10.1016/j.biomaterials.2005.04.028.

Abstract

Formation of calcium phosphate (Ca-P) on various bioceramic surfaces in simulated body fluid (SBF) and in rabbit muscle sites was investigated. The bioceramics were sintered porous solids, including bioglass, glass-ceramics, hydroxyapatite, alpha-tricalcium phosphate and beta-tricalcium phosphate. The ability of inducing Ca-P formation was compared among the bioceramics. The Ca-P crystal structures were identified using single-crystal diffraction patterns in transmission electron microscopy. The examination results show that ability of inducing Ca-P formation in SBF was similar among bioceramics, but considerably varied among bioceramics in vivo. Sintered beta-tricalcium phosphate exhibited a poor ability of inducing Ca-P formation both in vitro and in vivo. Octacalcium phosphate (OCP) formed on the surfaces of bioglass, A-W, hydroxyapatite and alpha-tricalcium phosphate in vitro and in vivo. Apatite formation in physiological environments cannot be confirmed as a common feature of bioceramics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apatites / chemistry
  • Biocompatible Materials / chemistry*
  • Body Fluids
  • Bone Substitutes
  • Calcium Phosphates / chemistry*
  • Ceramics / chemistry*
  • Coated Materials, Biocompatible
  • Durapatite / chemistry
  • In Vitro Techniques
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Muscles / metabolism
  • Rabbits
  • Surface Properties

Substances

  • Apatites
  • Biocompatible Materials
  • Bone Substitutes
  • Calcium Phosphates
  • Coated Materials, Biocompatible
  • alpha-tricalcium phosphate
  • beta-tricalcium phosphate
  • octacalcium phosphate
  • Durapatite
  • calcium phosphate
  • tricalcium phosphate