Abstract
[reaction: see text] Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including (1)H and (13)C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Crystallography, X-Ray
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Diterpenes
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Diterpenes, Clerodane* / chemistry
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Diterpenes, Clerodane* / isolation & purification
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Diterpenes, Clerodane* / pharmacology
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Molecular Structure
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Narcotic Antagonists*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Salvia / chemistry*
Substances
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Diterpenes
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Diterpenes, Clerodane
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Narcotic Antagonists
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neoclerodane
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salvinicin A
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salvinicin B