[Pathological and clinical correlations in primary cutaneous B-cell lymphomas: a series of 44 cases]

Ann Pathol. 2005 Feb;25(1):8-17. doi: 10.1016/s0242-6498(05)80094-x.
[Article in French]

Abstract

Aims: histological and clinical relationship study of 44 cases of primary cutaneous B cell lymphoma, classified according to WHO classification.

Materials and methods: histological, immunological and molecular analysis was correlated with clinical data.

Results: 33 cases (75%) were marginal zone B-cell lymphomas (MZL), with head and trunk predominance (median age = 54 years). Relapses in other mucosa-related sites occurred in 3 patients. Histological transformation implied a more aggressive treatment in 3 cases. A favorable outcome was observed in most cases. 9 (20%) diffuse large B-cell lymphomas (DLBCL) appeared as a unique nodule, with female predominance (median age = 74 years) and 4 lymphoma-related deaths which seemed age-related (> 70 years) with only one lower limb localization. Histological aggressive features were present in 3 patients with a fatal outcome. 2 (5%) WHO grade 3 follicular lymphomas (FL) had an heterogeneous phenotype, with head localization, cutaneous relapses and good outcome.

Conclusions: MZL, the predominant type, has a good prognosis, although transformation can occur, needing a more aggressive treatment. DLBCL, observed in older patients, has clinical and histological prognostic factors identical to extra-cutaneous lymphomas. FL appears rare and has an heterogeneous phenotype. Relationships with its nodal counterpart remains unclear.

Publication types

  • Case Reports
  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents / therapeutic use
  • DNA, Neoplasm / analysis
  • Fatal Outcome
  • Female
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Lymphoma, B-Cell / genetics
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, B-Cell / therapy
  • Lymphoma, Follicular / genetics
  • Lymphoma, Follicular / pathology
  • Lymphoma, Follicular / therapy
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Lymphoma, Large B-Cell, Diffuse / therapy
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Polymerase Chain Reaction
  • Radiotherapy
  • Remission Induction
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / therapy
  • Surgical Procedures, Operative

Substances

  • Antineoplastic Agents
  • DNA, Neoplasm