Abstract
COX-2 overexpression and subsequent PGE(2) production are frequently associated with non-small cell lung cancer and are implicated in tumor-mediated angiogenesis. Here, we report for the first time that IL-20 downregulates COX-2 and PGE(2) in human bronchial epithelial and endothelial cells. Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE(2) occurs through the IL-22R1/IL-20R2 dimers. In addition, we report that IL-20 exerts anti-angiogenic effects, inhibiting experimental angiogenesis. IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE(2) and inhibits angiogenesis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Angiogenesis Inhibitors / administration & dosage*
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Carcinoma, Non-Small-Cell Lung / metabolism*
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Cell Line, Tumor
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Cells, Cultured
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Cyclooxygenase 2
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Cytokines / administration & dosage
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Dinoprostone / metabolism*
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Dose-Response Relationship, Drug
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Gene Expression Regulation / drug effects
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Humans
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Interleukins / administration & dosage*
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Membrane Proteins
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Neovascularization, Pathologic / metabolism*
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Neovascularization, Pathologic / pathology
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Prostaglandin-Endoperoxide Synthases / metabolism*
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Respiratory Mucosa / drug effects
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Respiratory Mucosa / metabolism*
Substances
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Angiogenesis Inhibitors
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Cytokines
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Interleukins
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Membrane Proteins
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Cyclooxygenase 2
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases
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Dinoprostone
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interleukin 20