Abstract
Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA levels were studied in the course of murine herpes simplex virus encephalitis. Induction of GNDF and NT-3 (both P < 0.05) was found during acute encephalitis. Despite absence of clinical impairment, both neurotrophic factors were overexpressed 2 months (NT-3) and 6 months (GDNF) following infection (both P < 0.05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / metabolism*
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Brain / physiopathology
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Brain / virology*
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Brain Damage, Chronic / physiopathology
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Brain Damage, Chronic / prevention & control
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Brain Damage, Chronic / virology
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Brain-Derived Neurotrophic Factor / genetics
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Cell Survival / genetics
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Disease Models, Animal
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Encephalitis, Herpes Simplex / genetics*
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Encephalitis, Herpes Simplex / metabolism*
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Encephalitis, Herpes Simplex / physiopathology
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Female
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Gene Expression / physiology
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Glial Cell Line-Derived Neurotrophic Factor
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Mice
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Nerve Degeneration / physiopathology
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Nerve Degeneration / prevention & control
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Nerve Degeneration / virology
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Nerve Growth Factors / genetics*
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Neurotrophin 3 / genetics
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RNA, Messenger / metabolism*
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Recovery of Function / genetics
Substances
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Brain-Derived Neurotrophic Factor
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Gdnf protein, mouse
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Glial Cell Line-Derived Neurotrophic Factor
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Nerve Growth Factors
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Neurotrophin 3
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RNA, Messenger