Tag-team SUMO wrestling

Mol Cell. 2005 Jun 10;18(6):612-4. doi: 10.1016/j.molcel.2005.05.017.

Abstract

Structural and kinetic studies of a SUMORanGAP1-Ubc9-Nup358/RanBP2 complex (Reverter and Lima, 2005) provide the first high-resolution view of SUMO recognition by a SUMO binding motif and also reveal a novel mechanism for E3 ubiquitin-like protein ligases, with the Nup358/RanBP2 E3 teaming up with both SUMO and the E2 (Ubc9) to stimulate tagging.

MeSH terms

  • Molecular Chaperones
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / metabolism*
  • Nuclear Pore Complex Proteins
  • Protein Conformation
  • SUMO-1 Protein / chemistry
  • SUMO-1 Protein / metabolism*
  • Ubiquitin / chemistry
  • Ubiquitin / metabolism*
  • Ubiquitin-Conjugating Enzymes

Substances

  • Molecular Chaperones
  • Multiprotein Complexes
  • Nuclear Pore Complex Proteins
  • SUMO-1 Protein
  • Ubiquitin
  • ran-binding protein 2
  • Ubiquitin-Conjugating Enzymes