Polymer micelle with cross-linked ionic core

Tatiana K Bronich; Paul A Keifer; Luda S Shlyakhtenko; Alexander V Kabanov

doi:10.1021/ja043042m

Polymer micelle with cross-linked ionic core

J Am Chem Soc. 2005 Jun 15;127(23):8236-7. doi: 10.1021/ja043042m.

Authors

Tatiana K Bronich¹, Paul A Keifer, Luda S Shlyakhtenko, Alexander V Kabanov

Affiliation

¹ Department of Pharmaceutical Sciences and the Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. tbronich@unmc.edu

PMID: 15941228
DOI: 10.1021/ja043042m

Abstract

This work reports the design of polymer micelles with cross-linked ionic cores that display high stability. Block ionomer complexes were utilized as a micellar template for the synthesis of the cross-linked micelles. Such micelles represent hydrophilic nanospheres of core-shell morphology. The core comprises a network of the cross-linked polyanions, which is surrounded by the shell of hydrophilic PEO chains.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Calcium / chemistry
Cations, Divalent
Cross-Linking Reagents / chemistry
Drug Delivery Systems
Magnetic Resonance Spectroscopy
Micelles*
Microscopy, Electron, Transmission
Nanostructures / chemistry
Polyethylene Glycols / chemistry*
Polymethyl Methacrylate / chemistry*

Substances

Cations, Divalent
Cross-Linking Reagents
Micelles
Polyethylene Glycols
Polymethyl Methacrylate
Calcium