[Effects of acetylsalicylic acid and diquertin on platelet aggregation and hemorheological parameters in rats with cerebral ischemia]

Eksp Klin Farmakol. 2005 Mar-Apr;68(2):33-5.
[Article in Russian]

Abstract

Rats with model cerebral ischemia were treated over 5 days with acetylsalicylic acid (in a single daily dose of 50 mg/kg via a gastric tube). This treatment decreased the level of platelet aggregation, while producing no statistically significant effect upon hemorheogical indices. The combined treatment with a complex of acetylsalicylic acid and diquertin (50 and 10 mg/kg via a gastric tube, respectively) also produced the antiaggregant effect, but additionally reduced the blood viscosity, erythrocyte aggregation, and fibrinogen content in the blood plasma.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Aspirin / administration & dosage*
  • Blood Viscosity / drug effects
  • Brain Ischemia / blood*
  • Brain Ischemia / drug therapy
  • Drug Combinations
  • Erythrocyte Aggregation / drug effects
  • Fibrin / analysis
  • Male
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / administration & dosage*
  • Quercetin / administration & dosage*
  • Quercetin / analogs & derivatives*
  • Rats
  • Rats, Wistar

Substances

  • Drug Combinations
  • Platelet Aggregation Inhibitors
  • diquertin
  • Fibrin
  • Quercetin
  • Aspirin