Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy

Inflamm Res. 2005 Apr:54 Suppl 1:S27-9. doi: 10.1007/s00011-004-0412-z.
No abstract available

MeSH terms

  • Animals
  • Biphenyl Compounds / adverse effects
  • Biphenyl Compounds / chemistry
  • Biphenyl Compounds / pharmacology*
  • Diet
  • Dietary Fats / administration & dosage
  • Dietary Fats / pharmacology
  • Histamine Agonists / chemistry
  • Histamine Agonists / pharmacology
  • Histamine Antagonists / adverse effects
  • Histamine Antagonists / chemistry
  • Histamine Antagonists / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Molecular Structure
  • Nitriles / adverse effects
  • Nitriles / chemistry
  • Nitriles / pharmacology*
  • Obesity / chemically induced
  • Obesity / metabolism*
  • Obesity / prevention & control*
  • Pyrrolidines / adverse effects
  • Pyrrolidines / chemistry
  • Pyrrolidines / pharmacology*
  • Receptors, Histamine H3 / metabolism*

Substances

  • 4'-(3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy)-biphenyl-4-carbonitrile
  • Biphenyl Compounds
  • Dietary Fats
  • Histamine Agonists
  • Histamine Antagonists
  • Nitriles
  • Pyrrolidines
  • Receptors, Histamine H3