Sch 42137, a novel antifungal antibiotic from an Actinoplanes sp. Fermentation, isolation, structure and biological properties

R Cooper; I Truumees; I Gunnarsson; D Loebenberg; A Horan; J Marquez; M Patel; V Gullo; M Puar; P Das

doi:10.7164/antibiotics.45.444

Sch 42137, a novel antifungal antibiotic from an Actinoplanes sp. Fermentation, isolation, structure and biological properties

J Antibiot (Tokyo). 1992 Apr;45(4):444-53. doi: 10.7164/antibiotics.45.444.

Authors

R Cooper¹, I Truumees, I Gunnarsson, D Loebenberg, A Horan, J Marquez, M Patel, V Gullo, M Puar, P Das, et al.

Affiliation

¹ Microbial Products, Schering-Plough Research, Bloomfield, NJ 07003.

PMID: 1592676
DOI: 10.7164/antibiotics.45.444

Abstract

A novel polycyclic xanthone, Sch 42137, related to the albofungin family of compounds was isolated from culture broth. Its structure was determined by detailed spectroscopic studies and comparison of circular dichroic studies to related compounds albofungin and simaomicin. Sch 42137 exhibited MIC values less than 0.125 micrograms/ml against yeasts and dermatophytes. Details are presented herein.

MeSH terms

Actinomyces / chemistry*
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Candida / drug effects*
Chromatography, High Pressure Liquid
Circular Dichroism
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Microbiological Techniques
Trichophyton / drug effects*
Xanthenes / chemistry
Xanthenes / isolation & purification
Xanthenes / pharmacology

Substances

Antifungal Agents
Xanthenes
SCH 42137
albofungin