Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo

Phillip W Ingham; H Rosemary Kim

doi:10.1016/j.yexcr.2005.03.019

Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo

Exp Cell Res. 2005 Jun 10;306(2):336-42. doi: 10.1016/j.yexcr.2005.03.019. Epub 2005 Apr 21.

Authors

Phillip W Ingham¹, H Rosemary Kim

Affiliation

¹ Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK. p.w.ingham@sheffield.ac.uk

PMID: 15925589
DOI: 10.1016/j.yexcr.2005.03.019

Abstract

Signalling by members of the Hedgehog family of secreted proteins plays a central role in the development of many animal species. In the zebrafish embryo, the specification of myoblast fates is controlled by Hedgehog signals emanating from axial midline structures. Distinct muscle cell identities are induced by varying levels of signalling activity. The SET domain transcription factor, Blimp1, is a key target of Hedgehog signalling in this process.

Publication types

Review

MeSH terms

Animals
Cell Differentiation
DNA-Binding Proteins
Embryo, Nonmammalian / metabolism*
Embryonic Induction
Gene Expression Regulation, Developmental / physiology*
Hedgehog Proteins
Muscle, Skeletal / embryology*
Nuclear Proteins
Positive Regulatory Domain I-Binding Factor 1
Repressor Proteins / metabolism
Signal Transduction / physiology*
Trans-Activators / physiology*
Transcription Factors / metabolism
Zebrafish / embryology*
Zebrafish Proteins

Substances

DNA-Binding Proteins
Hedgehog Proteins
Nuclear Proteins
Repressor Proteins
Trans-Activators
Transcription Factors
Zebrafish Proteins
Positive Regulatory Domain I-Binding Factor 1
prdm1a protein, zebrafish