Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity

Int J Obes (Lond). 2005 Jul;29(7):872-4. doi: 10.1038/sj.ijo.0802973.

Abstract

Objective: To investigate whether genetic variation in the cyclic GMP-dependent protein kinase gene (PRKG1) is associated with obesity.

Methods: The study included 143 individuals from New York City area, NY, USA. The subjects were sampled on the basis of body mass index (BMI): obese (BMI ranging from 33.8 to 89.5 kg/m(2)), and nonobese (BMI ranging from 16.0 to 29.4 kg/m(2)). The association between C2276T polymorphism in PRKG1 gene and obesity was tested using linear regression analysis.

Results: BMI levels were predicted by linear regression models adjusted for demographic factors. An analysis was performed twice: in individuals of all ethnic backgrounds and in European-Americans only. In both cases, genotype did not have a significant effect.

Conclusion: We found no evidence that the C2276T polymorphism in the PKRG1 gene is associated with obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Cyclic GMP-Dependent Protein Kinases / genetics*
  • Female
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Obesity / enzymology
  • Obesity / genetics*
  • Phenotype
  • Polymorphism, Genetic*

Substances

  • Cyclic GMP-Dependent Protein Kinases