Translocation (6;16) in a case of granulosa cell tumor of the ovary

A Verhest; B Nedoszytko; J C Noel; J M Dangou; P Simon; J Limon

doi:10.1016/0165-4608(92)90231-v

Translocation (6;16) in a case of granulosa cell tumor of the ovary

Cancer Genet Cytogenet. 1992 May;60(1):41-4. doi: 10.1016/0165-4608(92)90231-v.

Authors

A Verhest¹, B Nedoszytko, J C Noel, J M Dangou, P Simon, J Limon

Affiliation

¹ Department of Pathology and Gynecology, Erasme Hospital, Free University of Brussels, Belgium.

PMID: 1591705
DOI: 10.1016/0165-4608(92)90231-v

Abstract

We performed a cytogenetic study of an ovarian granulosa cell tumor (GCT). Tumor cells showed a translocation (6;16); the full karyotype was 45,XX-6,dic(6;16)(q11;q22)/44,XX,-6,-22,dic(6;16)(q11;q22),-22/46,XX,- 6,dic(6;16)(q11;q22), +dic(6;16)(q11;q22). This is the second case of GCT with structural changes of chromosome 6 leading to loss of 6q material.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosomes, Human, Pair 16*
Chromosomes, Human, Pair 6*
Female
Granulosa Cell Tumor / genetics*
Granulosa Cell Tumor / pathology
Humans
Karyotyping
Ovarian Neoplasms / genetics*
Ovarian Neoplasms / pathology
Translocation, Genetic*