Identification of the MHC class I B locus in cynomolgus monkeys

Immunogenetics. 2005 May;57(3-4):189-97. doi: 10.1007/s00251-005-0782-6. Epub 2005 Mar 3.

Abstract

By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynomolgus MHC class I B locus might be duplicated and that the Mafa-I locus was derived from the B locus by gene duplication, as in the case of the Mamu-I locus of rhesus monkeys.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary / genetics
  • Female
  • Gene Duplication
  • Genes, MHC Class I*
  • Haplotypes
  • Macaca fascicularis / genetics*
  • Macaca fascicularis / immunology*
  • Macaca mulatta / genetics
  • Macaca mulatta / immunology
  • Male
  • Molecular Sequence Data
  • Pedigree
  • Phylogeny
  • Sequence Homology, Amino Acid
  • Species Specificity

Substances

  • DNA, Complementary

Associated data

  • GENBANK/AB154760
  • GENBANK/AB154761
  • GENBANK/AB154762
  • GENBANK/AB154763
  • GENBANK/AB154764
  • GENBANK/AB154765
  • GENBANK/AB154766
  • GENBANK/AB154767
  • GENBANK/AB154768
  • GENBANK/AB154769
  • GENBANK/AB154770
  • GENBANK/AB154771
  • GENBANK/AB154772
  • GENBANK/AB154773