A case of Aspergillus mediastinitis after heart transplantation successfully treated with liposomal amphotericin B, caspofungin and voriconazole

Eur J Clin Microbiol Infect Dis. 2005 May;24(5):347-9. doi: 10.1007/s10096-005-1327-5.

Abstract

Reported here is a case of mediastinitis caused by Aspergillus fumigatus and Staphylococcus epidermidis following a heart transplantation that was successfully treated with amphotericin B in combination with new antifungal drugs (caspofungin and voriconazole), antibiotics and superficial wound drainage. A review of the literature revealed that Aspergillus as a cause of mediastinitis has been rarely described. In the few existing reports, evolution was generally fatal, especially in immunocompromised patients, despite treatment with antifungal drugs and surgery.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Amphotericin B / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy*
  • Aspergillus fumigatus
  • Caspofungin
  • Echinocandins
  • Female
  • Heart Transplantation
  • Humans
  • Lipopeptides
  • Mediastinitis / drug therapy
  • Mediastinitis / microbiology*
  • Middle Aged
  • Peptides, Cyclic / therapeutic use*
  • Pyrimidines / therapeutic use*
  • Surgical Wound Infection / drug therapy
  • Surgical Wound Infection / microbiology
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Peptides, Cyclic
  • Pyrimidines
  • Triazoles
  • liposomal amphotericin B
  • Amphotericin B
  • Caspofungin
  • Voriconazole