Refractory coeliac disease: remission with infliximab and immunomodulators

Eur J Gastroenterol Hepatol. 2005 Jun;17(6):667-9. doi: 10.1097/00042737-200506000-00012.

Abstract

Coeliac disease is a T-cell-mediated enteropathy induced by gluten. A minority of patients who fail to respond to a gluten-free diet may require intervention with immunomodulating drugs. We report a case of refractory coeliac disease where remission was induced by the anti-tumour necrosis factor-alpha antibody infliximab and was maintained with prednisolone and azathioprine.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antibodies, Monoclonal / therapeutic use*
  • Celiac Disease / drug therapy*
  • Drug Therapy, Combination
  • Gastrointestinal Agents / therapeutic use*
  • Humans
  • Infliximab
  • Male
  • Prednisolone / therapeutic use
  • Remission Induction
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Antibodies, Monoclonal
  • Gastrointestinal Agents
  • Tumor Necrosis Factor-alpha
  • Prednisolone
  • Infliximab