Abstract
A commercial assay for detection of measles immunoglobulin G (IgG) in oral fluid was evaluated in a highly vaccinated cohort using serum IgG as gold standard. In contrast to previous studies from cohorts protected by natural immunity, antibody prevalence was significantly underestimated (-7.4%; confidence interval: -1.5 to -13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral / analysis*
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Antibody Formation / drug effects
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Cohort Studies
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Humans
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Immunoglobulin G / analysis*
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Measles / therapy*
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Measles Vaccine / pharmacology*
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Reagent Kits, Diagnostic / standards*
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Saliva / immunology
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Sensitivity and Specificity
Substances
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Antibodies, Viral
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Immunoglobulin G
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Measles Vaccine
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Reagent Kits, Diagnostic