Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Takashi Takahashi; Kazuoki Nakai; Takayuki Doi; Masa Yasunaga; Hiroshi Nakagawa; Toshihisa Ishikawa

doi:10.1016/j.bmcl.2005.03.038

Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Bioorg Med Chem Lett. 2005 May 16;15(10):2601-5. doi: 10.1016/j.bmcl.2005.03.038.

Authors

Takashi Takahashi¹, Kazuoki Nakai, Takayuki Doi, Masa Yasunaga, Hiroshi Nakagawa, Toshihisa Ishikawa

Affiliation

¹ Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan. ttak@apc.titech.ac.jp

PMID: 15863325
DOI: 10.1016/j.bmcl.2005.03.038

Abstract

We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / chemistry
ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology*
Bridged-Ring Compounds / chemistry*
Drug Resistance, Multiple*
Drug Resistance, Neoplasm*
Taxoids / chemistry*

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Bridged-Ring Compounds
Taxoids
taxane