Functional magnetic resonance imaging (fMRI) was used to examine the processing of infrequent changes occurring in an unattended sound sequence. In event-related brain potentials (ERPs), such sound changes typically elicit several responses, including an enhanced N1, the mismatch negativity (MMN), and the P3a. In the present study, subjects were presented with a repeating sound of 75 ms in duration, which was occasionally replaced, in separate blocks, by a 15-ms, 25-ms, or 35-ms sound (large, medium, and small change, respectively). In the baseline block, only the frequent 75-ms sound was presented. During the scanning, the subjects were instructed to ignore the sounds while watching a silent wildlife documentary. We assumed that in this condition, the MMN mechanism would contribute more to the observed activation than the other change-related processes. We expected sound changes to elicit fMRI activation bilaterally in the supratemporal cortices, where the electric MMN is mainly generated, and that the magnitude of this activation would increase with the magnitude of sound duration change. Unexpectedly, however, we found that only blocks with medium duration changes (25 ms) showed significant activation in the supratemporal cortex. In addition, as reported in some previous EEG and fMRI studies, contrasts between different levels of sound duration change revealed additional activation in the inferior frontal cortex bilaterally. This activation tended to be greater for the small and medium changes than for the large ones.