[Structure-function organization of neurokinin A and neurokinin B molecules. I. Theoretical conformational analysis of neurokinin A]

Biofizika. 2005 Mar-Apr;50(2):203-14.
[Article in Russian]

Abstract

The spatial structure of the neurokinin A molecule was studied by the method of theoretical conformational analysis. On the basis of fragmental analysis, stable structures of the neurokinin A molecule under polar conditions were determined. The structures can be described by four families of low-energy conformations having a relatively labile tripeptide at the C-end and a conformationally rigid heptapeptide at the N-end. It was shown that two of these conformations are virtually isoenergetic structures. One of these is an alpha-helical structure and the other forms two beta-turns at the N-terminus, which change to the turn of the alpha-helix at the C-end.

Publication types

  • English Abstract

MeSH terms

  • Amino Acid Sequence
  • Models, Molecular
  • Molecular Sequence Data
  • Neurokinin A / chemistry*
  • Neurokinin B / chemistry
  • Protein Conformation

Substances

  • Neurokinin A
  • Neurokinin B