Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus

G Garcia-Effron; E Mellado; A Gomez-Lopez; L Alcazar-Fuoli; M Cuenca-Estrella; Juan L Rodriguez-Tudela

doi:10.1128/AAC.49.5.2119-2121.2005

Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus

Antimicrob Agents Chemother. 2005 May;49(5):2119-21. doi: 10.1128/AAC.49.5.2119-2121.2005.

Authors

G Garcia-Effron¹, E Mellado, A Gomez-Lopez, L Alcazar-Fuoli, M Cuenca-Estrella, Juan L Rodriguez-Tudela

Affiliation

¹ Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo Km 2, 28220 Madrid, Spain.

Abstract

The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A(-) and one cyp51B(-) gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology*
Aspergillus fumigatus / drug effects
Aspergillus fumigatus / enzymology*
Azoles / pharmacology*
Cytochrome P-450 Enzyme System / metabolism*
Drug Interactions
Drug Resistance, Fungal
Drug Synergism
Fungal Proteins / metabolism*
Microbial Sensitivity Tests

Substances

Antifungal Agents
Azoles
Fungal Proteins
Cytochrome P-450 Enzyme System
cytochrome P-450 CYP51A, Aspergillus