Axon regeneration: it's getting crowded at the gates of TROY

Curr Biol. 2005 Apr 26;15(8):R302-5. doi: 10.1016/j.cub.2005.04.002.

Abstract

A novel neuronal receptor complex that mediates myelin's inhibitory action on nerve fiber regeneration has at last been identified. This discovery could be an important step towards promoting nerve regeneration after stroke or spinal cord injury.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Central Nervous System / physiology*
  • GPI-Linked Proteins
  • Ganglia, Spinal / metabolism
  • Membrane Proteins
  • Models, Molecular
  • Multiprotein Complexes / metabolism*
  • Myelin Proteins / metabolism
  • Myelin-Associated Glycoprotein / metabolism
  • Nerve Regeneration / physiology*
  • Nerve Tissue Proteins
  • Neurites / metabolism
  • Nogo Receptor 1
  • Receptor, Nerve Growth Factor
  • Receptors, Cell Surface / metabolism
  • Receptors, Nerve Growth Factor / metabolism
  • Receptors, Tumor Necrosis Factor / metabolism*
  • Signal Transduction / physiology*
  • rhoA GTP-Binding Protein / metabolism

Substances

  • GPI-Linked Proteins
  • LINGO1 protein, human
  • Membrane Proteins
  • Multiprotein Complexes
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Nerve Tissue Proteins
  • Nogo Receptor 1
  • RTN4R protein, human
  • Receptor, Nerve Growth Factor
  • Receptors, Cell Surface
  • Receptors, Nerve Growth Factor
  • Receptors, Tumor Necrosis Factor
  • TNFRSF19 protein, human
  • rhoA GTP-Binding Protein