Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes

J Bone Miner Metab. 2005;23(3):200-4. doi: 10.1007/s00774-004-0598-8.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Development
  • Cell Differentiation*
  • Cell Proliferation*
  • Chondrocytes / pathology*
  • Cyclic GMP-Dependent Protein Kinase Type II
  • Cyclic GMP-Dependent Protein Kinases / genetics*
  • Dwarfism / genetics*
  • Dwarfism / pathology
  • Growth Plate / pathology
  • High Mobility Group Proteins / genetics
  • Mutation
  • Rats
  • SOX9 Transcription Factor
  • Signal Transduction
  • Transcription Factors / genetics

Substances

  • High Mobility Group Proteins
  • SOX9 Transcription Factor
  • Transcription Factors
  • Cyclic GMP-Dependent Protein Kinase Type II
  • Cyclic GMP-Dependent Protein Kinases
  • Prkg2 protein, rat