Towards multifunctional antioxidants: synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties

Org Biomol Chem. 2005 Apr 21;3(8):1541-6. doi: 10.1039/b503282m. Epub 2005 Mar 18.

Abstract

Numerous human diseases are linked to a biochemical condition known as oxidative stress (OS). Antioxidants are therefore becoming increasingly important as potential disease prevention and therapeutic agents. Since OS is a multi-stressor event, agents combining a range of different antioxidant properties, such as redox catalysis and metal binding, might be more effective and selective than mono-functional agents. Selenium derivatives of aniline and pyridine combine redox activity with metal binding properties. These multifunctional agents have a distinct electrochemical profile, and exhibit good catalytic activity in the glutathione peroxidase mimic and metallothionein assays. They also show antioxidant activity in a skin cell model of UVA-induced stress. These compounds might therefore provide the basis for novel agents combining two or more distinct antioxidant properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Catalysis
  • Cell Line
  • Copper / chemistry
  • Electrochemistry
  • Fibroblasts
  • Humans
  • Ligands
  • Molecular Structure
  • Peroxidase / metabolism
  • Reactive Oxygen Species / chemistry

Substances

  • Antioxidants
  • Ligands
  • Reactive Oxygen Species
  • Copper
  • Peroxidase