Early cessation of triptorelin in in vitro fertilization: a double-blind, randomized study

Fertil Steril. 2005 Apr;83(4):889-96. doi: 10.1016/j.fertnstert.2004.10.044.

Abstract

Objective: To compare the efficacy of two early cessation protocols of triptorelin treatment in controlled ovarian hyperstimulation with the conventional long protocol in in vitro fertilization/intracytoplasmic sperm injection.

Design: A double-blind, randomized, multicenter study.

Setting: Three Dutch hospitals.

Patient(s): One hundred seventy-eight women randomized to one of three treatment groups at the start of stimulation.

Intervention(s): Midluteally started triptorelin administration was continued until the first day of hMG treatment (group S), or up to and including the fourth day of hMG treatment (group M) or the day of hCG injection (group L).

Main outcome measure(s): Occurrence of a premature LH surge.

Result(s): One premature LH surge was observed in group M but not in groups S and L. Both early cessation protocols (S and M) are at least as effective as the long protocol (L) with regard to the number of oocytes (11.1 and 10.3 vs. 9.3), number of embryos (7.3 and 6.5 vs. 5.5), and ongoing pregnancy rate (28% and 24% vs. 21%).

Conclusion(s): Early cessation of triptorelin on day 1 of hMG treatment in a midluteally started IVF protocol is as effective as the traditional long protocol in preventing a premature LH surge and results in similar fertility effects.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Fertility Agents, Female / administration & dosage
  • Fertilization in Vitro*
  • Humans
  • Infertility, Female / drug therapy*
  • Luteinizing Hormone / blood
  • Luteolytic Agents / administration & dosage*
  • Luteolytic Agents / adverse effects
  • Menotropins / administration & dosage
  • Ovarian Follicle / cytology
  • Ovarian Follicle / drug effects
  • Ovulation Induction / methods*
  • Pregnancy
  • Pregnancy Outcome
  • Sperm Injections, Intracytoplasmic
  • Triptorelin Pamoate / administration & dosage*
  • Triptorelin Pamoate / adverse effects

Substances

  • Fertility Agents, Female
  • Luteolytic Agents
  • Triptorelin Pamoate
  • Menotropins
  • Luteinizing Hormone