Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

M F Ross; G F Kelso; F H Blaikie; A M James; H M Cochemé; A Filipovska; T Da Ros; T R Hurd; R A J Smith; M P Murphy

doi:10.1007/s10541-005-0104-5

Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

Biochemistry (Mosc). 2005 Feb;70(2):222-30. doi: 10.1007/s10541-005-0104-5.

Authors

M F Ross¹, G F Kelso, F H Blaikie, A M James, H M Cochemé, A Filipovska, T Da Ros, T R Hurd, R A J Smith, M P Murphy

Affiliation

¹ MRC Dunn Human Nutrition Unit, Cambridge, CB2 2XY, UK.

PMID: 15807662
DOI: 10.1007/s10541-005-0104-5

Abstract

Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cations / chemistry
Cations / metabolism
Energy Metabolism / physiology*
Free Radicals / metabolism
Humans
Intracellular Membranes / metabolism
Mitochondria / metabolism
Mitochondria / physiology*
Models, Biological
Molecular Structure
Organophosphorus Compounds / chemistry
Organophosphorus Compounds / metabolism*

Substances

Cations
Free Radicals
Organophosphorus Compounds