Diffuse normolipemic plane xanthoma in a 9-year-old boy

Pediatr Dermatol. 2005 Mar-Apr;22(2):127-9. doi: 10.1111/j.1525-1470.2005.22207.x.

Abstract

Normolipemic plane xanthoma normally occurs in adults. We report the atypical instance of a 9-year-old boy who developed disseminated, flat, yellow-brown plaques up to 2 to 3 cm without any complaints. The histology showed the hallmarks of xanthoma, including the presence of CD68+ foam cells and Touton giant cells. No systemic involvement or lipid disorders were evident. It is important to perform regular follow-up of these patients because normolipemic plane xanthoma often precedes myeloproliferative disorders such as leukemia, paraproteinemia, or lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD / metabolism
  • Antigens, Differentiation, Myelomonocytic / metabolism
  • Biopsy
  • Child
  • Humans
  • Male
  • Skin Diseases / metabolism
  • Skin Diseases / pathology*
  • Xanthomatosis / metabolism
  • Xanthomatosis / pathology*

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD68 antigen, human